Day: May 8, 2020

Optimizing adaptive cancer therapy: dynamic programming and evolutionary game theory

1. Background

Intratumoural heterogeneity is increasingly recognized as a cause of metastasis, progression and resistance to therapy [1]. While genetic instability, a hallmark of malignancy [2], can result in this heterogeneity, it is being increasingly understood that eco-evolutionary factors, like selection and clonal interference, can also drive and maintain it [3,4].

While sequencing technologies have enabled increasingly in-depth quantitative understanding of the genetic heterogeneity, relatively little experimental work has sought to directly quantify the eco-evolutionary interactions involved. As more studies come to light showing the efficacy of treatments based on eco-evolutionary trial designs, this lack of quantification is coming into focus.

In line with standard, cell-autonomous growth-based theories, conventional chemotherapy is given to patients at the maximum tolerated doses (MTD): the highest doses that most patients can safely tolerate. Although the MTD-based therapy offers advantages in survival compared to no therapy, cures remain elusive, and side effects can be severe.

Read More

Internet Speed Test + Deals From Internet Providers in Your Area

Run the Speed Test & Get High Speed Internet Service

At Bandwidth Place, we are not only an online speed test tool developers. We also partner with the top Internet providers in the United States letting you compare plans to find the best Internet Service Provider (ISP) to meet your household’s needs. We will find you high speed broadband service with most affordable Internet plan in your area to connect multiple devices at your home: desktops, laptops, smartphones, tablets, security cameras and home alarms, video game systems and even other smart home devices, like Amazon Echo and Alexa, and Google Home. If you are moving or want to upgrade your Internet or bundled digital home services, simply call us and we will check availability and recommend the best plan. When it comes to Internet service and plans it’s your choice: you decide! 

Our accurate Internet speed test is designed to

Read More

MrBayes | index

MrBayes | index

Vetenskapsradet Naturhistoriska Riksmuseet National Bioinformatics Infrastructure Sweden (NBIS)
National Institutes of Health National Science Foundation

MrBayes is a program for Bayesian inference and model choice
across a wide range of phylogenetic and evolutionary models.
MrBayes uses Markov chain Monte Carlo (MCMC) methods to estimate
the posterior distribution of model parameters.

Program features include:

  • A common command-line interface across Macintosh, Windows,
    and UNIX operating systems;
  • Extensive help available from the command line;
  • Analysis of nucleotide, amino acid, restriction site, and
    morphological data;
  • Mixing of data types, such as molecular and morphological
    characters, in a single analysis;
  • Easy linking and unlinking of parameters across data
    partitions;
  • An abundance of evolutionary models, including 4×4, doublet,
    and codon models for nucleotide data and many of the standard
    rate matrices for amino acid data;
  • Estimation of positively selected sites in a fully
    hierarchical Bayesian framework;
  • Full integration of the BEST algorithms for the multi-species
    coalescent;
  • Estimation of time calibrated (clock)
Read More

Rocket Internet | Crunchbase

Read More

How Changing Technology Affects Security

Security is a tradeoff, a balancing act between attacker and defender. Unfortunately, that balance is never static. Changes in technology affect both sides. Society uses new technologies to decrease what I call the scope of defection — what attackers can get away with — and attackers use new technologies to increase it. What’s interesting is the difference between how the two groups incorporate new technologies.

Changes in security systems can be slow. Society has to implement any new security technology as a group, which implies agreement and coordination and — in some instances — a lengthy bureaucratic procurement process. Meanwhile, an attacker can just use the new technology. For example, at the end of the horse-and-buggy era, it was easier for a bank robber to use his new motorcar as a getaway vehicle than it was for a town’s police department to decide it needed a police car, get the

Read More

Pixar’s computer graphics pioneers have won the $1 million Turing Award

Two men who invented game-changing 3D computer graphics techniques now widely used in the film industry have won the highest distinction in computer science: the Turing Award. If you enjoyed Toy Story, The Lord of the Rings, Finding Nemo, Titanic, Avatar, or Jurassic Park, you have them to thank.

Who are they? Edwin Catmull and Patrick Hanrahan. Catmull cofounded Pixar and hired biophysics PhD Hanrahan as one of the first employees in 1986. Hanrahan spent much of his time modeling materials and lighting to help animations look closer to real life. “Physicists generally don’t study hair or skin, and why they look the way they do. I did, and spent years thinking about how to get things like lighting right,” he told MIT Technology Review.

Their work: Hanrahan was the lead architect of the team that created the complex software known as RenderMan, which

Read More

ITSM, Service Desk & Help Desk Software with integrated ITAM

Lexy Ewing

Director of IT, Digital MD Systems








Capterra

“I appreciate SysAid’s ease of submission of tickets for my clients. They are very good at keeping track of the important things for my company.”

Jonathan Purvis

IT Manager, Kefron








Capterra

“SysAid truly is the number one helpdesk resource for IT admins, from ticket logging to self-service account unlocks – it has it all. But not only that, SysAid listens to its customers.”

Jon S.

Network & SysAdmin, Wimsatt Building Materials








G2 Crowd

“Incredibly powerful and feature rich service desk. …Control virtually every aspect of the service desk and customize it to your liking. Amazing customer support and online community.”

Source Article Read More

Missouri Assistive Technology


  • Follow Missouri Assistive Technology on Twitter, Youtube, facebook and Pinterest




Welcome to MoAT!

Missouri Assistive Technology strives to increase access to assistive technology for Missourians with all types of disabilities, of all ages. To the right are navigation links to the programs and services of MoAT.

 

We’re Glad to Be Back!

We are even more pleased to let you know that all of our programs and services are fully operational again. We remain committed to assuring the health and well-being of all Missourians as we work to address your assistive technology needs.

 


MoAT Service Snapshot

In State FY 2019, MoAT delivered 7,640 assistive devices and provided support services to 23,671 Missourians with disabilities, family members and professionals.




Count

 Topic

1.931

  Assistive devices loaned

2,006

  Device demonstrations conducted

2,020

  TAP for Telephone & Internet devices provided

Read More

Computer Science Lab Home Page: Learn Computer Programming


This unique computer curriculum offers 3 different environments of graduated
complexity: a programmable RPN (Reverse Polish Notation) calculator, an Intel
8051 microprocessor that is programmed using assembly language, and finally the
high-level C and C++ languages.


Each of these 3 languages comes complete with an
integrated development environment
(IDE) that provides an editor, compiler, and debugger. You
get fully explained solutions to fun programming projects such as
a scrolling electronic signboard, a robotic mouse in a maze, an audio
peak detector using an LED bar graph, and the Breakout video game.
All of these example programs have been designed to be highly visual,
audible, and fun.
In addition to the introduction to assembly language programming and
the introduction to C and C++, this curriculum offers an introduction to
Windows programming and graphical user interfaces.
You can find screen shots and further description of each of

Read More

Handbook Processing.org

Processing: A Programming Handbook for Visual Designers (Second Edition)
by Casey Reas and Ben Fry.
Published December 2014, The MIT Press.
720 Pages. Hardcover.

» Order from MIT Press
» Order from Amazon

» Download Examples
» Errata

If you are an educator, you can request a desk/exam copy from the MIT Press website.

Since it first emerged in 2001, Processing has grown into a flourishing community of thousands of artists, designers, makers, and educators. It has redrawn the boundaries of art and technology, affecting communities in contexts as various as the classroom to the art museum to the hackerspace. After 12 years of development and being intensively taught in classrooms, the second edition of the Processing textbook was released in December 2014.

By teaching computer programming with the context of the visual arts, this book has introduced a new literacy with software, enabling designers and artists to create new media for the present, and to imagine future media

Read More